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Publication : C.H. Waddington's differences with the creators of the modern evolutionary synthesis: a tale of two genes.

First Author  Bard Jonathan B L Year  2017
Journal  Hist Philos Life Sci Volume  39
Pages  18 PubMed ID  28791592
Abstract Text  In 2011, Peterson suggested that the main reason why C.H. Waddington was essentially ignored by the framers of the modern evolutionary synthesis in the 1950s was because they were Cartesian reductionists and mathematical population geneticists while he was a Whiteheadian organicist and experimental geneticist who worked with Drosophila. This paper suggests a further reason that can only be seen now. The former defined genes and their alleles by their selectable phenotypes, essentially the Mendelian view, while Waddington defined a gene through its functional role as determined by genetic analysis, a view that foresaw the modern view that a gene is a DNA sequence with some function. The former were interested in selection, while Waddington focused on variation. The differences between the two views of a gene are briefly considered in the context of systems biology. Doi  10.1007/s40656-017-0143-4
Issue  3 Month  Aug

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