| First Author | Freeman S M | Year | 1987 |
| Journal | Hum Immunol | Volume | 19 |
| Pages | 1-6 | PubMed ID | 2884201 |
| Abstract Text | Insulin-dependent diabetes (IDD) is positively associated with HLA-D proteins. A critical question is whether or not sequence differences within the HLA-D coding region are the same or different in diabetics and normal individuals of the same haplotype. We have isolated both DR beta 1 alleles from a Dw4/LD MN2 cDNA library and compared them to DR beta 1 genes isolated from normal individuals of the same Dw phenotype. We found no nucleotide differences in the coding region between the normal and diabetic alleles of DR beta 1 suggesting to us that DNA differences other than the DR beta 1 coding region may account for the observed association of HLA-D and diabetes. | Doi | 10.1016/0198-8859(87)90033-4 |
| Issue | 1 | Month | May |
