| First Author | Ludlow C | Year | 1996 |
| Journal | Dev Biol | Volume | 178 |
| Pages | 149-59 | PubMed ID | 8812116 |
| Abstract Text | The cut locus acts as a bimodal switch controlling cell fate in the peripheral nervous system of Drosophila and is also required for the development of the wing margin. It encodes a protein, Cut, that contains an atypical homeodomain and three copies of a new motif which can bind DNA in vitro. The human protein CDP and the murine protein Cux have recently been isolated as DNA-binding activities and they are structurally related to Cut. We show that ectopic expression of Cut, CDP, or Cux similarly affects embryonic sensory organ development and can rescue a wing scalloping mutant phenotype associated with loss of cut expression along the prospective wing margins. This suggests that the function of Cut is evolutionarily conserved. | Doi | 10.1006/dbio.1996.0205 |
| Issue | 1 | Month | Aug |
