| First Author | Bisgrove Dwayne A | Year | 2007 |
| Journal | Proc Natl Acad Sci U S A | Volume | 104 |
| Pages | 13690-5 | PubMed ID | 17690245 |
| Abstract Text | We have identified a conserved region in the C-terminal domain of bromodomain-containing protein 4 (BRD4) that mediates its specific interaction with positive transcription elongation factor b (P-TEFb). This domain is highly conserved in testis-specific bromodomain protein (BRDT) and Drosophila fs(1)h. Both BRDT and fs(1)h specifically interact with P-TEFb in mammalian cells, and this interaction depends on their C-terminal domains. Overexpression of the BRD4 P-TEFb-interacting domain disrupts the interaction between the HIV transactivator Tat and P-TEFb and suppresses the ability of Tat to transactivate the HIV promoter. Incubation of cells with a synthetic peptide containing the C-terminal domain of BRD4 interferes with transactivation of the HIV promoter by the Tat protein. | Doi | 10.1073/pnas.0705053104 |
| Issue | 34 | Month | Aug |
