| First Author | Zhang Qing | Year | 2021 |
| Journal | Sci Total Environ | Volume | 762 |
| Pages | 144170 | PubMed ID | 33360465 |
| Abstract Text | Triclosan (TCS) is widely used as an antibacterial agent, but its residue in the environment poses a great threat. In this study, Drosophila melanogaster were treated with series concentrations of TCS and the effects on development, behavior, reproduction, and oxidative stress indicators were investigated. The results showed that high concentrations of TCS severely interfered with the metamorphosis, resulting in lower hatching rate and longer development time. The hatching rate was only 75.00% ± 4.08% in 0.80 mg/mL TCS group. TCS also showed dose-dependent damage to the fertility of flies, causing ovarian defects and decreased the number of offspring. Almost no offspring adults hatched when exposed to high concentrations of TCS (0.50 and 0.80 mg/mL), and the hatching rate was 0% in 0.80 mg/mL TCS group. Larvae crawling, adult climbing and anti-starvation ability were also affected to varying degrees and showed hormesis. TCS could damage larval intestinal cells in a dose-dependent manner, and injury was lightened with culture time prolonging to 30 h. It is noteworthy that TCS caused redox imbalance with an increase on catalase (CAT) activity and decrease on reactive oxygen species (ROS) level. Our results conclude that TCS elicits multiple impacts on Drosophila and its rational use should be strengthened. | Doi | 10.1016/j.scitotenv.2020.144170 |
| Month | Mar |
