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Publication : Mutations in genes cnc or dKeap1 modulate stress resistance and metabolic processes in Drosophila melanogaster.

First Author  Bayliak Maria M Year  2020
Journal  Comp Biochem Physiol A Mol Integr Physiol Volume  248
Pages  110746 PubMed ID  32579905
Abstract Text  EY08884caused by insertion of P{EPgy2} transposon in cnc promotor did not affect significantly the levels of metabolites and redox parameters, and even activated some components of antioxidant defense. These data suggest that the mutation can be hypomorphic as well as CncC protein can be dispensable for adult fruit flies under physiological conditions. In females, CncC mutation led to lower mitochondrial respiration, higher hexokinase activity and higher fecundity as compared with the control line. Either CncC activation or its deficiency affected stress resistance of flies. Doi  10.1016/j.cbpa.2020.110746
Month  10

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