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Publication : GAL4-responsive UAS-tau as a tool for studying the anatomy and development of the Drosophila central nervous system.

First Author  Ito K Year  1997
Journal  Cell Tissue Res Volume  290
Pages  1-10 PubMed ID  9377629
Abstract Text  To improve the quality of cytoplasmic labelling of GAL4-expressing cells in Drosophila enhancer-trap and transgenic strains, a new GAL4-responsive reporter UAS-tau, which features a bovine tau cDNA under control of a yeast upstream activation sequence (UAS), was tested. Tau, a microtubule-associated protein, is distributed actively and evenly into all cellular processes. Monoclonal anti-bovine Tau antibody reveals the axonal structure of the labelled cells with detail similar to that of Golgi impregnation. We demonstrate that the UAS-tau system is especially useful for studying processes of differentiation and reorganisation of identified neurones during postembryonic development. Doi  10.1007/s004410050901
Issue  1 Month  Oct

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