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Publication : Nucleo-cytoplasmic shuttling of Drosophila Hairless/Su(H) heterodimer as a means of regulating Notch dependent transcription.

First Author  Wolf Dorina Year  2019
Journal  Biochim Biophys Acta Mol Cell Res Volume  1866
Pages  1520-1532 PubMed ID  31326540
Abstract Text  ⁎NLS3mutant cells, demonstrating nuclear requirement for its activity. Importantly, we reveal that Su(H) protein strictly follows Hairless protein localization. Together, we propose that shuttling between the nucleo-cytoplasmic compartments provides the possibility to fine tune the regulation of Notch target gene expression by balancing of Su(H) protein availability for Notch activation. Doi  10.1016/j.bbamcr.2019.07.008
Issue  10 Month  10

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