| First Author | Dominado Nicole | Year | 2016 |
| Journal | Stem Cell Reports | Volume | 7 |
| Pages | 1152-1163 | PubMed ID | 27974223 |
| Abstract Text | 11null allele. We demonstrate that Rbf promotes cell-cycle exit and differentiation of the somatic and germline stem cells of the testes. Intriguingly, depletion of Rbf specifically in the germline does not disrupt stem cell differentiation, rather Rbf loss of function in the somatic lineage drives overproliferation and differentiation defects in both lineages. Together our observations suggest that Rbf in the somatic lineage controls germline stem cell renewal and differentiation non-autonomously via essential roles in the microenvironment of the germline lineage. | Doi | 10.1016/j.stemcr.2016.11.007 |
| Issue | 6 | Month | 12 |
