| First Author | Du Qianqian | Year | 2021 |
| Journal | Front Neurosci | Volume | 15 |
| Pages | 673684 | PubMed ID | 34140878 |
| Abstract Text | Drosophilalarvae. Knockdown experiments showed that the bidirectional mcGO movements were cooperatively controlled by the dynein heavy chain (Dhc) and kinesin heavy chain subunits. Notably, only Dhc mediated APP's regulation of mcGO movements. Furthermore, by loss-of-function screening, the adaptor protein Sunday driver (Syd) was identified to mediate the APP-induced alteration of the direction of mcGO movements and dendritic defects. Collectively, by elucidating a model of bidirectional mcGO movements, we revealed the mechanism by which APP regulates the direction of mcGO movements. Our study therefore provides new insights into AD pathogenesis. | Doi | 10.3389/fnins.2021.673684 |
