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Publication : Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons.

First Author  Mosca Timothy J Year  2017
Journal  Elife Volume  6
PubMed ID  28606304 Abstract Text  Breceptors. LRP4 overexpression increases synapse number in excitatory and inhibitory neurons, suggesting an instructive role and a common downstream synapse addition pathway. Mechanistically, LRP4 functions via the conserved kinase SRPK79D to ensure normal synapse number and behavior. This highlights a presynaptic function for LRP4, enabling deeper understanding of how synapse organization is coordinated.
Doi  10.7554/eLife.27347 Month  06

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