| First Author | Batut Philippe J | Year | 2017 |
| Journal | Elife | Volume | 6 |
| PubMed ID | 29260710 | Abstract Text | Drosophilaspecies. Core promoters, generally not thought to play a significant regulatory role, in fact impart restrictions on the developmental timing of gene expression on a global scale. We propose a hierarchical regulatory model in which core promoters define broad windows of opportunity for expression, by defining a range of transcription factors from which they can receive regulatory inputs. This two-tiered mechanism globally orchestrates developmental gene expression, including extremely widespread noncoding transcription. The sequence and expression specificity of noncoding RNA promoters are evolutionarily conserved, implying biological relevance. Overall, this work introduces a hierarchical model for developmental gene regulation, and reveals a major role for noncoding transcription in animal development. |
| Doi | 10.7554/eLife.29005 | Month | 12 |
