| First Author | Nguyen Minh Binh | Year | 2016 |
| Journal | Development | Volume | 143 |
| Pages | 3506-3513 | PubMed ID | 27702784 |
| Abstract Text | extWing notching resulting from reduced levels of Ebi is suppressed by decreasing the Crb function. Consistent with this antagonistic genetic relationship, Ebi knockdown in the DV boundary elevates the Crb protein level. Furthermore, we show that Ebi is required for downregulation of Crb by ubiquitylation. Taken together, we propose that the interplay of Crb expression in the DV boundary and ubiquitin-dependent Crb downregulation by Ebi provides a mechanism for the maintenance of Notch signaling during wing development. | Doi | 10.1242/dev.142059 |
| Issue | 19 | Month | 10 |
