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Publication : Guidance of cell migration by the Drosophila PDGF/VEGF receptor.

First Author  Duchek P Year  2001
Journal  Cell Volume  107
Pages  17-26 PubMed ID  11595182
Abstract Text  Directed cell migrations are important for development, but the signaling pathways and mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration of border cells during Drosophila oogenesis is a simple and attractive model system in which to address these questions. We demonstrate that PVR, a receptor tyrosine kinase related to mammalian PDGF and VEGF receptors, acts in border cells to guide them to the oocyte. The oocyte is the source of a ligand for PVR, PDGF/VEGF factor 1 (PVF1). Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal. Doi  10.1016/s0092-8674(01)00502-5
Issue  1 Month  Oct

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