| First Author | Hu Deqing | Year | 2013 |
| Journal | Mol Cell | Volume | 51 |
| Pages | 493-505 | PubMed ID | 23932780 |
| Abstract Text | The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their promoter structure, selectivity for either RNA polymerase (Pol) II or III, and because of their unique mechanism of termination that is tightly linked with the promoter. Recently, we identified the little elongation complex (LEC) in Drosophila that is required for the expression of Pol II-transcribed snRNA genes. Here, using Drosophila and mammalian systems, we provide genetic and molecular evidence that LEC functions in at least two phases of snRNA transcription: an initiation step requiring the ICE1 subunit, and an elongation step requiring ELL. | Doi | 10.1016/j.molcel.2013.07.003 |
| Issue | 4 | Month | Aug |
