| First Author | Bausek Nina | Year | 2013 |
| Journal | JAKSTAT | Volume | 2 |
| Pages | e25686 | PubMed ID | 24069566 |
| Abstract Text | JAK-STAT signaling is a highly conserved regulator of stem cells and their niches. Aberrant activation in hematopoietic stem cells is the underlying cause of a majority of myeloproliferative diseases. This review will focus on the roles of JAK-STAT activity in three different adult stem cell systems in Drosophila. Tightly controlled levels of JAK-STAT signaling are required for stem cell maintenance and self-renewal, as hyperactivation of the pathway is associated with stem cell overproliferation. JAK-STAT activity is further essential for anchoring the stem cells in their respective niches by regulating different adhesion molecules. | Doi | 10.4161/jkst.25686 |
| Issue | 3 | Month | Jul |
