| First Author | Lin F K | Year | 1993 |
| Journal | Biochim Biophys Acta | Volume | 1173 |
| Pages | 325-8 | PubMed ID | 7916636 |
| Abstract Text | Cynomolgus monkey renal kallikrein cDNA and genomic human tissue kallikrein gene were cloned. The monkey gene encodes a 257 amino acid (aa) preprokallikrein and exhibits 95% and 92% homology to the human at nucleotide (nt) and aa level, respectively. The monkey gene encodes a 233-aa mature kallikrein versus a 238-aa in human. The human kallikrein gene and urinary kallikrein both contain a Lys-162 instead of the reported Glu-162. Human, monkey and rat renal/pancreatic kallikrein genes evolve with a N-glycosylation containing domain (aa 81-87) which is absent in porcine and is non-glycosylable in mice. Only human kallikrein evolves with an additional Thr-108 and with a N-glycosylation site at aa-141. | Doi | 10.1016/0167-4781(93)90131-v |
| Issue | 3 | Month | Jun |
