| First Author | Julian Lisa D | Year | 2008 |
| Journal | J Med Chem | Volume | 51 |
| Pages | 3953-60 | PubMed ID | 18553955 |
| Abstract Text | We report the discovery of potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1). The optimization and correlation of in vitro and in vivo metabolic stability will be described. Through modifications to our initial lead 2, we discovered pyridyl compound 13. This compound has a favorable pharmacokinetic profile across three species and showed a dose-dependent decrease in adipose 11beta-HSD1 activity in a monkey ex vivo pharmacodynamic model. | Doi | 10.1021/jm800310g |
| Issue | 13 | Month | Jul |
