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Publication : Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity.

First Author  Constance William D Year  2018
Journal  Elife Volume  7
PubMed ID  29504935 Abstract Text  Drosophilafor studying the development of complex arborisations live, in vivo during metamorphosis. In growing arborisations we see branch dynamics and localisations of presynaptic proteins very similar to the 'synaptotropic growth' described in fish/frogs. These accumulations of presynaptic proteins do not appear to be presynaptic release sites and are not paired with neurotransmitter receptors. Knockdowns of either evoked or spontaneous neurotransmission do not impact arbor growth. Instead, we find that axonal branch growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin. These adhesion complexes provide stability for filopodia by a 'stick-and-grow' based mechanism wholly independent of synaptic activity.
Doi  10.7554/eLife.31659 Month  03

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