help  | about  | cite  | software

Publication : A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development.

First Author  Orian Amir Year  2007
Journal  Proc. Natl. Acad. Sci. U.S.A. Volume  104
Pages  15771-6 PubMed ID  17898168
Abstract Text  Integration of patterning cues via transcriptional networks to coordinate gene expression is critical during morphogenesis and misregulated in cancer. Using DNA adenine methyltransferase (Dam)ID chromatin profiling, we identified a protein-protein interaction between the Drosophila Myc oncogene and the Groucho corepressor that regulates a subset of direct dMyc targets. Most of these shared targets affect fate or mitosis particularly during neurogenesis, suggesting the dMyc-Groucho complex may coordinate fate acquisition with mitotic capacity during development. We find an antagonistic relationship between dMyc and Groucho that mimics the antagonistic interactions found for EGF and Notch signaling: dMyc is required to specify neuronal fate and enhance neuroblast mitosis, whereas Groucho is required to maintain epithelial fate and inhibit mitosis. Our results suggest that the dMyc-Groucho complex defines a previously undescribed mechanism of Myc function and may serve as the transcriptional unit that integrates EGF and Notch inputs to regulate early neuronal development. Doi  10.1073/pnas.0707418104
Issue  40 Month  Oct

Publication Annotations Displayer

29 Entities

14 Mesh Terms