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Publication : Transcriptional silencing of homeotic genes in Drosophila.

First Author  Bienz M Year  1995
Journal  Bioessays Volume  17
Pages  775-84 PubMed ID  8763830
Abstract Text  Homeotic genes are subject to transcriptional silencing, which prevents their expression in inappropriate body regions. Here, we shall focus on Drosophila, as little is known about this process in other organisms. Evidence is accumulating that silencing of Drosophila homeotic genes is conferred by two types of cis- regulatory sequences: initiation (SIL-1) and maintenance (SIL-M) elements. The former contain target sites for transient repressors with a highly localised distribution in the early embryo and the latter for constitutive repressors that are likely to be present in all cells. We discuss how SIL-1 elements may cooperate with SIL-M elements to promote formation of a silencing complex. We propose that this complex consists of specific non-histone proteins, the so-called Polycomb group proteins, and that it is anchored at SIL-M elements and at the promoter. Doi  10.1002/bies.950170907
Issue  9 Month  Sep

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