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Publication : Senseless acts as a binary switch during sensory organ precursor selection.

First Author  Jafar-Nejad Hamed Year  2003
Journal  Genes Dev. Volume  17
Pages  2966-78 PubMed ID  14665671
Abstract Text  During sensory organ precursor (SOP) specification, a single cell is selected from a proneural cluster of cells. Here, we present evidence that Senseless (Sens), a zinc-finger transcription factor, plays an important role in this process. We show that Sens is directly activated by proneural proteins in the presumptive SOPs and a few cells surrounding the SOP in most tissues. In the cells that express low levels of Sens, it acts in a DNA-binding-dependent manner to repress transcription of proneural genes. In the presumptive SOPs that express high levels of Sens, it acts as a transcriptional activator and synergizes with proneural proteins. We therefore propose that Sens acts as a binary switch that is fundamental to SOP selection. Doi  10.1101/gad.1122403
Issue  23 Month  Dec

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