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Publication : Drosophilamodel of amyotrophic lateral sclerosis.

First Author  Chaplot Kriti Year  2019
Journal  Dis Model Mech Volume  12
PubMed ID  30635270 Abstract Text  Drosophilalarval brain was developed in order to validate the hits from the cell-based screen. In the larval brain, we find that reduction of SOD1 levels or decreased mTOR signalling reduces aggregation, presumably by increasing the levels of cellular reactive oxygen species (ROS). The mechanism of aggregate clearance is, primarily, proteasomal degradation, which appears to be triggered by an increase in ROS. We have thus uncovered an interesting interplay between SOD1, ROS and mTOR signalling that regulates the dynamics of VAP aggregation. Mechanistic processes underlying such cellular regulatory networks will lead to better understanding of the initiation and progression of ALS.This article has an associated First Person interview with the first author of the paper.
Doi  10.1242/dmm.033803 Issue  2
Month  02

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