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Publication : Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function.

First Author  Bradley Pamela L Year  2003
Journal  Dev. Biol. Volume  257
Pages  249-62 PubMed ID  12729556
Abstract Text  The final overall shape of an organ and its position within the developing embryo arise as a consequence of both its intrinsic properties and its interactions with surrounding tissues. Here, we focus on the role of directed cell migration in shaping and positioning the Drosophila salivary gland. We demonstrate that the salivary gland turns and migrates along the visceral mesoderm to become properly oriented with respect to the overall embryo. We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman, but does not require a differentiated visceral mesoderm. We also demonstrate a role for integrin function in salivary gland migration. Although the mutations affecting salivary gland motility and directional migration cause defects in the final positioning of the salivary gland, most do not affect the length or diameter of the salivary gland tube. These findings suggest that salivary tube dimensions may be an intrinsic property of salivary gland cells. Doi  10.1016/s0012-1606(03)00103-9
Issue  2 Month  May

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