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Publication : Accessorizing and anchoring the LINC complex for multifunctionality.

First Author  Chang Wakam Year  2015
Journal  J. Cell Biol. Volume  208
Pages  11-22 PubMed ID  25559183
Abstract Text  The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 (SUN) proteins, respectively, connects the nucleus to cytoskeletal filaments and performs diverse functions including nuclear positioning, mechanotransduction, and meiotic chromosome movements. Recent studies have shed light on the source of this diversity by identifying factors associated with the complex that endow specific functions as well as those that differentially anchor the complex within the nucleus. Additional diversity may be provided by accessory factors that reorganize the complex into higher-ordered arrays. As core components of the LINC complex are associated with several diseases, understanding the role of accessory and anchoring proteins could provide insights into pathogenic mechanisms. Doi  10.1083/jcb.201409047
Issue  1 Month  Jan

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