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Publication : Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes.

First Author  Ibrahim Daniel M Year  2013
Journal  G3 (Bethesda) Volume  3
Pages  1353-62 PubMed ID  23749451
Abstract Text  Signaling between cells in the anterior (A) and posterior (P) compartments directs Drosophila wing disc development and is dependent on expression of the homeodomain transcription factor Engrailed (En) in P cells. Downstream of en, posteriorly expressed Hedgehog (Hh) protein signals across the A/P border to establish a developmental organizer that directs pattern formation and growth throughout the wing primordium. Here we extend investigations of the processes downstream of en by using expression array analysis to compare A and P cells. A total of 102 candidate genes were identified that express differentially in the A and P compartments; four were characterized: Stubble (Sb) expression is restricted to A cells due to repression by en. CG15905, CG16884; CG10200/hase und igel (hui) are expressed in A cells downstream of Hh signaling; and RNA interference for hui, Stubble, and CG16884 revealed that each is essential to wing development. Doi  10.1534/g3.113.006569
Issue  8 Month  Aug

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