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Publication : Interplay of mechanical deformation and patterned gene expression in developing embryos.

First Author  Brouzés Eric Year  2004
Journal  Curr. Opin. Genet. Dev. Volume  14
Pages  367-74 PubMed ID  15261652
Abstract Text  The shaping of the early embryo requires pattern formation as well as geometric and topological morphogenesis of the developing tissues. The morphogenetic movements that lead to geometric shape changes are controlled by patterned gene expression. How particular movements are related to patterning genes, and which underlying molecular and cellular mechanisms lead to coordinated macroscopic movements that induce morphogenesis, remain the challenging questions of embryonic development. How morphogenetic movements could modulate the expression of developmental genes is an emerging question, potentially opening new horizons in developmental biology. This question instigates the task of characterizing the molecular and cellular mechanisms underlying these mechano-transcription events. Doi  10.1016/j.gde.2004.06.005
Issue  4 Month  Aug

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