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Publication : Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance.

First Author  Charron Frédéric Year  2005
Journal  Development Volume  132
Pages  2251-62 PubMed ID  15857918
Abstract Text  During embryonic development, morphogens act as graded positional cues to dictate cell fate specification and tissue patterning. Recent findings indicate that morphogen gradients also serve to guide axonal pathfinding during development of the nervous system. These findings challenge our previous notions about morphogens and axon guidance molecules, and suggest that these proteins, rather than having sharply divergent functions, act more globally to provide graded positional information that can be interpreted by responding cells either to specify cell fate or to direct axonal pathfinding. This review presents the roles identified for members of three prominent morphogen families--the Hedgehog, Wnt and TGFbeta/BMP families--in axon guidance, and discusses potential implications for the molecular mechanisms underlying their guidance functions. Doi  10.1242/dev.01830
Issue  10 Month  May

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