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Publication : Evolution of enzyme cascades from embryonic development to blood coagulation.

First Author  Krem Maxwell M Year  2002
Journal  Trends Biochem. Sci. Volume  27
Pages  67-74 PubMed ID  11852243
Abstract Text  Recent delineation of the serine protease cascade controlling dorsal-ventral patterning during Drosophila embryogenesis allows this cascade to be compared with those controlling clotting and complement in vertebrates and invertebrates. The identification of discrete markers of serine protease evolution has made it possible to reconstruct the probable chronology of enzyme evolution and to gain new insights into functional linkages among the cascades. Here, it is proposed that a single ancestral developmental/immunity cascade gave rise to the protostome and deuterostome developmental, clotting and complement cascades. Extensive similarities suggest that these cascades were built by adding enzymes from the bottom of the cascade up and from similar macromolecular building blocks. Doi  10.1016/s0968-0004(01)02007-2
Issue  2 Month  Feb

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