| First Author | Andrew David R | Year | 2021 |
| Journal | J Neurogenet | Volume | 35 |
| Pages | 1-22 | PubMed ID | 33164597 |
| Abstract Text | CASK-related neurodevelopmental disorders, displayed consistently elevated grooming indices throughout the assay, but transient locomotory activation immediately after placement in the arena. Based on published data identifying FMRP-target transcripts and functional analyses of mutations causing human genetic neurodevelopmental disorders, we propose the following proteins as candidate mediators of excessive repetitive behaviors in FXS: CaMKIIα, NMDA receptor subunits 2A and 2B, NLGN3, and SHANK3. Together, these fly-mutant phenotypes and mechanistic insights provide starting points for drug discovery to identify compounds that reduce dysfunctional repetitive behaviors. | Doi | 10.1080/01677063.2020.1833005 |
| Issue | 1 | Month | Mar |
