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Publication : Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells.

First Author  de Navascués Joaquín Year  2012
Journal  EMBO J Volume  31
Pages  2473-85 PubMed ID  22522699
Abstract Text  The Drosophila adult posterior midgut has been identified as a powerful system in which to study mechanisms that control intestinal maintenance, in normal conditions as well as during injury or infection. Early work on this system has established a model of tissue turnover based on the asymmetric division of intestinal stem cells. From the quantitative analysis of clonal fate data, we show that tissue turnover involves the neutral competition of symmetrically dividing stem cells. This competition leads to stem-cell loss and replacement, resulting in neutral drift dynamics of the clonal population. As well as providing new insight into the mechanisms regulating tissue self-renewal, these findings establish intriguing parallels with the mammalian system, and confirm Drosophila as a useful model for studying adult intestinal maintenance. Doi  10.1038/emboj.2012.106
Issue  11 Month  May

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