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Publication : Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila.

First Author  Yu Q Journal  Nature
Volume  326 Pages  765-9
PubMed ID  3106823 Abstract Text  The period gene of Drosophila melanogaster, implicated in the control of both the circadian and male courtship song rhythms, is found to be polymorphic. Alleles differ in the length of a region of the gene encoding a series of threonine-glycine repeat units. The phenotypes of transformed fruit flies, in which the only functional period gene lacks the entire perfect threonine-glycine repeat region, show that the effects of the period gene on the circadian and male courtship song rhythms can be dissociated.
Doi  10.1038/326765a0 Issue  6115

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