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Publication : Mechanisms of scaling in pattern formation.

First Author  Umulis David M Year  2013
Journal  Development Volume  140
Pages  4830-43 PubMed ID  24301464
Abstract Text  Many organisms and their constituent tissues and organs vary substantially in size but differ little in morphology; they appear to be scaled versions of a common template or pattern. Such scaling involves adjusting the intrinsic scale of spatial patterns of gene expression that are set up during development to the size of the system. Identifying the mechanisms that regulate scaling of patterns at the tissue, organ and organism level during development is a longstanding challenge in biology, but recent molecular-level data and mathematical modeling have shed light on scaling mechanisms in several systems, including Drosophila and Xenopus. Here, we investigate the underlying principles needed for understanding the mechanisms that can produce scale invariance in spatial pattern formation and discuss examples of systems that scale during development. Doi  10.1242/dev.100511
Issue  24 Month  Dec

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