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Publication : Fringe, Notch, and making developmental boundaries.

First Author  Irvine K D Year  1999
Journal  Curr. Opin. Genet. Dev. Volume  9
Pages  434-41 PubMed ID  10449349
Abstract Text  Multiple mechanisms are involved in positioning and restricting specialized dorsal-ventral border cells in the Drosophila wing, including modulation of Notch signaling by Fringe, autonomous inhibition by Notch ligands, and inhibition of Notch target genes by Nubbin. Recent studies have revealed that Fringe also modulates a Notch-mediated signaling process between dorsal and ventral cells in the Drosophila eye, establishing an organizer of eye growth and patterning along the dorsal-ventral midline. Fringe-dependent modulation of Notch signaling also plays a key role in Drosophila leg segmentation and growth. Lunatic Fringe has been shown to be required for vertebrate somitogenesis, where it appears to act as a crucial link between a molecular clock and the regulation of Notch signaling. Doi  10.1016/S0959-437X(99)80066-5
Issue  4 Month  Aug

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