help  | about  | cite  | software

Publication : The Nap family proteins, CG5017/Hanabi and Nap1, are essential for Drosophila spermiogenesis.

First Author  Kimura Shuhei Year  2013
Journal  FEBS Lett. Volume  587
Pages  922-9 PubMed ID  23454210
Abstract Text  Spermiogenesis is a dynamic process leading to alterations in cell morphology. In spermiogenesis, the roles of the histone chaperones are largely unknown. Here, I report the unexpected roles of two Nap family proteins, CG5017/Hanabi and nucleosome assembly protein 1 (Nap1) in Drosophila. Hanabi is mainly localized in the cytoplasm, and the hanabi mutant shows fully scattered nuclei and abnormality of nuclear shaping in spermatid elongation. In contrast, Nap1 is localized at the apical tip of the sperm head, and the nap1 mutant exhibits disruption of the nuclear bundle in the later stage. These findings imply that Nap family proteins might individually sustain cytoskeleton-based morphogenesis, rather than histone biogenesis. Doi  10.1016/j.febslet.2013.02.019
Issue  7 Month  Apr

Publication Annotations Displayer

1 Authors

16 Entities

21 Mesh Terms