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Publication : Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression.

First Author  Kim Jongmin Year  2017
Journal  Science Volume  356
Pages  717-721 PubMed ID  28522526
Abstract Text  Drosophilamale germline stem cell lineage that a spermatocyte-specific zinc finger protein, Kumgang (Kmg), working with the chromatin remodeler dMi-2 prevents transcription of genes normally expressed only in somatic lineages. By blocking transcription from normally cryptic promoters, Kmg restricts activation by Aly, a component of the testis-meiotic arrest complex, to transcripts for male germ cell differentiation. Our results suggest that as new regions of the genome become open for transcription during terminal differentiation, blocking the action of a promiscuous activator on cryptic promoters is a critical mechanism for specifying precise gene activation. Doi  10.1126/science.aal3096
Issue  6339 Month  05

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