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Publication : Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids.

First Author  Zhang Tianyi Year  2017
Journal  Proc. Natl. Acad. Sci. U.S.A. Volume  114
Pages  E7469-E7478 PubMed ID  28827348
Abstract Text  Axinmutants by identifying bortezomib and additional peptide boronic acids. We show that the suppressive effect of peptide boronic acids on hyperactive Wnt signaling is dependent on α-catenin; the rescue effect is completely abolished with the depletion of α-catenin in adipocytes. These results indicate that rather than targeting the canonical Wnt signaling pathway directly, pharmacologic modulation of β-catenin activity through α-catenin is a potentially attractive approach to attenuating Wnt signaling in vivo. Doi  10.1073/pnas.1621048114
Issue  36 Month  09

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