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Publication : Sensing of amino acids in a dopaminergic circuitry promotes rejection of an incomplete diet in Drosophila.

First Author  Bjordal Marianne Year  2014
Journal  Cell Volume  156
Pages  510-21 PubMed ID  24485457
Abstract Text  The brain is the central organizer of food intake, matching the quality and quantity of the food sources with organismal needs. To ensure appropriate amino acid balance, many species reject a diet lacking one or several essential amino acids (EAAs) and seek out a better food source. Here, we show that, in Drosophila larvae, this behavior relies on innate sensing of amino acids in dopaminergic (DA) neurons of the brain. We demonstrate that the amino acid sensor GCN2 acts upstream of GABA signaling in DA neurons to promote avoidance of the EAA-deficient diet. Using real-time calcium imaging in larval brains, we show that amino acid imbalance induces a rapid and reversible activation of three DA neurons that are necessary and sufficient for food rejection. Taken together, these data identify a central amino-acid-sensing mechanism operating in specific DA neurons and controlling food intake. Doi  10.1016/j.cell.2013.12.024
Issue  3 Month  Jan

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