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Publication : Mechanisms of spindle positioning: focus on flies and worms.

First Author  Gönczy Pierre Year  2002
Journal  Trends Cell Biol. Volume  12
Pages  332-9 PubMed ID  12185850
Abstract Text  Accurate spindle positioning is crucial for spatial control of cell division. During metazoan development, coordination between polarity cues and spindle position also ensures correct segregation of cell fate determinants. Converging evidence indicates that spindle positioning is achieved through interactions between cortical anchors and the plus ends of microtubules, generating pulling forces acting on spindle poles. This article discusses recent findings that indicate how this mechanism might be used for spindle positioning during Drosophila and Caenorhabditis elegans development. Issue  7
Month  Jul

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