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Publication : Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in Drosophila.

First Author  Gorfinkiel Nicole Year  2007
Journal  J. Cell. Sci. Volume  120
Pages  3289-98 PubMed ID  17878238
Abstract Text  Dynamic interactions between epithelial sheets are a regular feature of morphogenetic processes. Dorsal closure in Drosophila relies on the coordinated movements of two epithelia, the epidermis and the amnioserosa, and provides an excellent model system for a genetic and cell biological approach. Here, we have analyzed the contribution of junctional organization of these epithelia to dorsal closure. We observe a stringent requirement for adherens junctions at the leading edge, the interface between the amnioserosa and the epidermis, for the transmission of the forces generated during the process. We also find that interactions between Armadillo and E-cadherin play an important role in maintaining the adhesion at the leading edge, revealing the particular dynamics of this interface. Our results show that regulated cell adhesion is a crucial element of the interactions that shape epithelial sheets in morphogenetic processes. Doi  10.1242/jcs.010850
Issue  Pt 18 Month  Sep

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