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Publication : Preventing neurodegeneration in the Drosophila mutant bubblegum.

First Author  Min K T Year  1999
Journal  Science Volume  284
Pages  1985-8 PubMed ID  10373116
Abstract Text  The Drosophila melanogaster recessive mutant bubblegum (bgm) exhibits adult neurodegeneration, with marked dilation of photoreceptor axons. The bubblegum mutant shows elevated levels of very long chain fatty acids (VLCFAs), as seen in the human disease adrenoleukodystrophy (ALD). In ALD, the excess can be lowered by dietary treatment with "Lorenzo's oil,"a mixture of unsaturated fatty acids. Feeding the fly mutant one of the components, glyceryl trioleate oil, blocked the accumulation of excess VLCFAs as well as development of the pathology. Mutant flies thus provide a potential model system for studying mechanisms of neurodegenerative disease and screening drugs for treatment. Doi  10.1126/science.284.5422.1985
Issue  5422 Month  Jun

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