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Publication : Complex Polarity: Building Multicellular Tissues Through Apical Membrane Traffic.

First Author  Román-Fernández Alvaro Year  2016
Journal  Traffic Volume  17
Pages  1244-1261 PubMed ID  27281121
Abstract Text  The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization. What is much less appreciated is that underpinning an asymmetric cell surface is an equally dramatic intracellular endosome rearrangement. Here, we review the interplay between classical cell polarity proteins and membrane trafficking pathways, and discuss how this marriage gives rise to cell polarization. We focus on those mechanisms that regulate apical polarization, as this is providing a number of insights into how membrane traffic and polarity are regulated at the tissue level. Doi  10.1111/tra.12417
Issue  12 Month  12

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