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Publication : Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll.

First Author  Liu Dawei Year  2015
Journal  Oncotarget Volume  6
Pages  38552-65 PubMed ID  26462024
Abstract Text  Chromosomal instability (CIN) is a hallmark of cancer and has been implicated in cancer initiation, progression and the development of resistance to traditional cancer therapy. Here we identify a new property of CIN cells, showing that inducing CIN in proliferating Drosophila larval tissue leads to the activation of innate immune signalling in CIN cells. Manipulation of this immune pathway strongly affects the survival of CIN cells, primarily via JNK, which responds to both Toll and TNFα/Eiger. This pathway also activates Mmp1, which recruits hemocytes to the CIN tissue to provide local amplification of the immune response that is needed for effective elimination of CIN cells. Doi  10.18632/oncotarget.6035
Issue  36 Month  Nov

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