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Publication : Light-induced structural and functional plasticity in Drosophila larval visual system.

First Author  Yuan Quan Year  2011
Journal  Science Volume  333
Pages  1458-62 PubMed ID  21903815
Abstract Text  How to build and maintain a reliable yet flexible circuit is a fundamental question in neurobiology. The nervous system has the capacity for undergoing modifications to adapt to the changing environment while maintaining its stability through compensatory mechanisms, such as synaptic homeostasis. Here, we describe our findings in the Drosophila larval visual system, where the variation of sensory inputs induced substantial structural plasticity in dendritic arbors of the postsynaptic neuron and concomitant changes to its physiological output. Furthermore, our genetic analyses have identified the cyclic adenosine monophosphate (cAMP) pathway and a previously uncharacterized cell surface molecule as critical components in regulating experience-dependent modification of the postsynaptic dendrite morphology in Drosophila. Doi  10.1126/science.1207121
Issue  6048 Month  Sep

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