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Publication : The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis.

First Author  van Eeden F Year  1999
Journal  Curr. Opin. Genet. Dev. Volume  9
Pages  396-404 PubMed ID  10449356
Abstract Text  Recent work on Drosophila oogenesis has begun to reveal how the first asymmetries in development arise and how these relate to the later events that localise the positional cues which define the embryonic axes. The Cadherin-dependent positioning of the oocyte creates an anterior-posterior polarity that is transmitted to the embryo through the localisation and localised translation of bicoid, oskar, and nanos mRNA. In contrast, dorsal-ventral polarity arises from the random migration of the nucleus to the anterior of the oocyte, where it determines where gurken mRNA is translated and localised. Gurken signalling then defines the embryonic dorsal-ventral axis by restricting pipe expression to the ventral follicle cells, where Pipe regulates the production of an unidentified cue that activates the Toll signalling pathway. Doi  10.1016/S0959-437X(99)80060-4
Issue  4 Month  Aug

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