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Publication : Getting knotted: a model for the structure and activation of Spätzle.

First Author  Mizuguchi K Year  1998
Journal  Trends Biochem. Sci. Volume  23
Pages  239-42 PubMed ID  9697410
Abstract Text  Sequence analyses show that Spätzle, the Drosophila melanogaster Toll-receptor ligand, shows striking similarity to nerve growth factor and coagulogen. Comparative modelling suggests that Spätzle adopts a cystine-knot fold and forms a dimer that contains a single, intermolecular disulphide bridge. Proteolytically cleaved Spätzle could therefore dimerize and activate the Toll receptor by inducing receptor dimerization. Issue  7
Month  Jul

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