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Publication : Drosophilasensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2.

First Author  DeVault Laura Year  2018
Journal  Genes Dev. Volume  32
Pages  402-414 PubMed ID  29563183
Abstract Text  Drosophilasensory system, which has a dendritic arbor that undergoes dramatic remodeling during the first 3 d of adult life and then maintains a relatively stable morphology thereafter. Using a laser severing paradigm, we monitored regeneration after acute and spatially restricted injury. We found that the capacity for regeneration was present in adult neurons but diminished as the animal aged. Regenerated dendrites recovered receptive function. Furthermore, we found that the regenerated dendrites show preferential alignment with the extracellular matrix (ECM). Finally, inhibition of ECM degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration. These results demonstrate that dendrites retain regenerative potential throughout adulthood and that regenerative capacity decreases with aging. Doi  10.1101/gad.308270.117
Issue  5-6 Month  03

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