help  | about  | cite  | software

Publication : Mechanism of suppression in Drosophila: control of sepiapterin synthase at the purple locus.

First Author  Yim J J Year  1977
Journal  Science Volume  198
Pages  1168-70 PubMed ID  412253
Abstract Text  The amounts of sepiapterin and red pteridine eye pigments (drosopterins) in Drosophila melanogaster are known to be reduced in the purple mutant and restored to normal by a suppressor mutation. We show here that sepiapterin synthase activity is 30 percent of normal in pr and prbw, two naturally occurring alleles of purple, and is restored to nearly normal levels by the suppressor su(s)2. A heterozygote of two newly induced alleles of pr has even lower enzyme activity (less than 10 percent). The sepiapterin synthase activity is proportional to the number of wild-type pr alleles in flies when one and two copies of the allele are present and is higher in three-than in two-dose flies. We hypothesize that the purple locus may be a structural gene for sepiapterin synthase in Drosophila. Issue  4322
Month  Dec

Publication Annotations Displayer

6 Entities

12 Mesh Terms