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Publication : Drosophilaand human FHOD family formin proteins nucleate actin filaments.

First Author  Patel Aanand A Year  2018
Journal  J. Biol. Chem. Volume  293
Pages  532-540 PubMed ID  29127202
Abstract Text  DrosophilaFhod binds tightly to barbed ends, where it slows elongation in the absence of profilin and allows, but does not accelerate, elongation in the presence of profilin. Fhod antagonizes capping protein but dissociates from barbed ends relatively quickly. Finally, we determined that Fhod binds the sides of and bundles actin filaments. This work establishes that Fhod shares the capacity of other formins to nucleate and bundle actin filaments but is notably less effective at processively elongating barbed ends than most well studied formins. Doi  10.1074/jbc.M117.800888
Issue  2 Month  Jan

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