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Publication : Single mesodermal cells guide outgrowth of ectodermal tubular structures in Drosophila.

First Author  Wolf C Year  2000
Journal  Genes Dev. Volume  14
Pages  2140-5 PubMed ID  10970878
Abstract Text  The Drosophila tracheal system, a tubular network, is formed from isolated ectodermal metameres by guided branch outgrowth and branch fusion. Branch outgrowth is triggered by the localized and transient activity of Branchless (Bnl/dFGF). Here, we report the discovery of a mesodermal cell that links the leading cells of outgrowing main branches 2.5 hr before they fuse. This bridge-cell serves as an essential guidance post and needs Hunchback (Hb) activity to exert its function. The bridge-cell provides cues acting in concert with Bnl/dFGF signaling to mediate directed branch outgrowth that ultimately leads to position-specific branch fusion. Issue  17
Month  Sep

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